Most people know Deadpool for constantly breaking the fourth wall and talking directly to the readers (or even the writers and illustrators). These breaks are often hilarious and act as great pop-culture references. Unfortunately, there is a darker undertone to these moments. With the self-awareness of knowing he is nothing more than a character in a comic book and at the dispense of the writers, Deadpool has been seen as discouraged and pained by his existence.
In fact, there have been several times in which Deadpool has addressed the existence of the fourth wall as something emotionally crushing. As we see in Deadpool Kills The Marvel Universe and Deadpool Roasts The Marvel Universe, Wade is unbelievably depressed by the weight of knowing that he exists only as a means of entertainment for all of us.